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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a978fcca644580c1fa8788ca0b8290d1e5d13588940ab9e3ede2482c1e6e284' 
  AND token = 'oq1Z4MkEpSDFERf+kEanpk8Ctk4Q7nWPUm+qQ7neAQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00044

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}