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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74a8e8524e0127ce9ea42888c5561304e9515b6611bbfc42cfb85e6d735eb2bd' 
  AND token = 'INl1+GcWoQjsJ2x6LzLFBOrbpp3nxYKR0mbpZmT7Cj4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00012

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}