SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a59e0f48c94870016b28685653f14817c6ed03bd8baa157b0178037f20f2626' 
  AND token = '9CuuLnUyn/EGcnAc+xvcYCEhoWUVlgpXmQAb227HUhg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}