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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8728f8581bb5bd751b186bc070cd366a1218b9f8eb076ae3c686f22da3a96b7c' 
  AND token = '+1sTNrSCzHNuAUsUc1Qjs+AB35kkNj3rRzOeZcXeJ0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}