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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8478a45317d2653898d16b23108f125a7ce4dd36e8848fc8e76a729d216f331' 
  AND token = 'V9i1UlKSShI1uSE6OEJhNgHzHdgYgn+aPCKkLd36Vhk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}