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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b146dc1b1c5fa4e3b7a118dd9016035a1472246b416772734ab56cf277c09726' 
  AND token = 'SwRynW1hQhxqc6p3tPg+9g2Qx4Kq5/HO61HqyxURjRg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}