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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1ec81788fcf88d3ed2c21e85cf8f1596fe3fcc47b56a2d1df70f968d1e9e6205' 
  AND token = 't5/fWM79Ln0MgmWiNxcTzyfuUAMGZGtmD9uDgX4+4qs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}