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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e975520e0dea06f51a4a25d9d7fb4046ecc929b7fc2b2790b1d48bc84a147ad' 
  AND token = 'JY3y1fc61qS5//1hF1EYs+/qb5IXxzmfhlMZ0wuFC9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}