SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '012d8cc7fb7ac2ae7a0c924842673e7e0cc848abec3a64b22f8599272823dbef' 
  AND token = '78O6ZhmrkCiKCQGm4vmwCKUUcL0t9I7T1SvZz4TtRlc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}