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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '486d47a0629b9e33d59d284d8f47905a22952c76639a96ea682fa5c072a74300' 
  AND token = 'SXn6OY2Lq3dK0BULmuKnEKce3yS2c5JUhrpVyHf2tSI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}