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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f114efa17de963b08e0f67c5ae43c2eb073a107e235ad167d08b28bb87a6faa' 
  AND token = 'EvpiTXOlQ/MslN3Txn15UWuu2YY52hAQGkzm1/5oaZ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}