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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52e03b423569efc100276486a974e4b6d020fda9f81217e47520cc03a497f746' 
  AND token = '43WOUkFwHqPAdWuFW/NUa2DIiygt1yw/ID+LDk+KT/Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}