SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '782721d204561285ee5c8c630603b8db058a3510e788fb7e7fe63842437d0918' 
  AND token = 'uc2ySh9g92tdXkiqt5MRQBsmG4ZBFstIIsI+ihxrrvA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}