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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18be41dd6a082d2b088f2dbc24b649d0f4012280cec80cc75a06e1d0c281570d' 
  AND token = '/nPDFgdvGyl5+R+3y6A3NghRO+kqpmBLxFCO2SjGlPo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}