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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '377e91cb27361fd7f1c75cebd0ba7241fcdc17c4e4219282f45b33e57a5da943' 
  AND token = 'LJtBEFLZWSSR7e+bBpAN0EqTvVG8URA4WYaFZ8n4+rE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}