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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b99e983ced7f38264d8da3f80ef3bef75c2082ff4fa570c84b34d09651ddb425' 
  AND token = 'kmckTgGQOo/38UA54o35ttKfoZ7IyGiFRK4gBc9fnUY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}