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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '425327e1c4cc94a85d9d2df0f2b51a3a290d6383508b6b819251098e03407b8a' 
  AND token = 'lT7xAjBbpmbW4vuRUOzFxo2/CPAjjcTgjhXRTnyU8E0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}