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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e99dd360d1a09ee34d1aa0ed999e6a2a5d2d2a9022556f149cad3ba5c85305b2' 
  AND token = 'z/Y1SQlThpLV79Y7glOEF/vClIqhYHHL7BLdMXdUMAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}