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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b1e06bd759b99400e33fd2f599df65b18243b05001c223eaf1a21c6f71251c62' 
  AND token = 'ou747U+GigVJal2EhZPnwAoa2IIMZJEDwI0Y8PW3FM0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}