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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0164146cb49416d086307b8a77bbcb74b29ecbc0be7eaf414ea547468a2bc3af' 
  AND token = 'dv0VKQ+osf47PTGTlfUAY4M/Oo7pTQUPQ9Uah6Zcf5k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}