SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16f4115e4dacdacc2d5ebe274a37012a908642d8ba3140dbb6be4480770fb466' 
  AND token = 'AmNob/Tmr2vodCvbC4N/KlWzCaqFPjwhV/eG2G9Z/mY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}