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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721e33d460b9f711c8bf9cf3c9e09e0b7a47a52009e4000d39caa4fac9b2aeb4' 
  AND token = '2XfFR6xA1+M+hYVjW+90vXi/fs5w501dql3X+HVlZg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}