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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781516ca8a2002578a5afca93c30ce45058d2b467793d74530136c36f0dfb927' 
  AND token = '37h0u6raWAgpKNNbql0SG2U2OSTEpSPezs9hFIkqSKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}