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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a270a475b9c9903706b0317b1b1d3e67f008e93798374a0335210f25bc22a005' 
  AND token = 'X6mvPEmVz53d+0/YQ7awqF5SWKNdRAE/4JWzTAYL2Qc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}