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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8225c1dad5eaa4dfcc3d99ccf29a2f0bc7d824037d6259153b0022c5bcdb958c' 
  AND token = 'DNtPVF/bKdVEE026cogNN+PxCtvq/cndO4gQ2Wf/VmY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}