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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '68800788ab0c53661a551e1808596ee34c7c8b02001290d9348194f4a0c11de9' 
  AND token = '+qvcOlnyjhwQFQCa8K2Z6LOSqbMb6HxL0qIJrW2CQ88=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}