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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4046374d848214845b55464e80ec30d2a946e0f65069b8dd3497d56189b3c54' 
  AND token = 'fWmuCoE1oMEnSVnrGpKOtrxHUnv2ks74zKe+kOGbTAw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}