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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd45fd59f78e95615f08f1b1916635b0be253307451b82dc960df63135986e80a' 
  AND token = 'y9bbQFC3ihNSI2uU/cZtDTY1MKT3nt67abY1n5SdOkQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}