SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '372eee1cc373fb1d27aff5446ed8f6a173255ab0d5a6e556dd1e461c48bd4644' 
  AND token = 'fbHfYhLCHkjWqeaSaI7rL7gvTf3/4+qKvOfqK1tEn2s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}