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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7218b5355dc47033cdc71cc3221e9db4bc561c02ef2cc5f393a5f77ec7e705bd' 
  AND token = 'pOVXNkmNgsKYL3le710TCOT1K7Bc5FtUgqm4T8Jd6Z8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}