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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78e046238961e9f0e66e7ba8eba193b8d26102ed1b0d52aab09195e4ef5c335d' 
  AND token = 'qhu7SoOhB0cgrZTZ9d5tbxdgFV5dPctRND1QhNy0GC8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}