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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8caf166270ad63bded3a802b27a4b2b3ada0063909ee8a25117ae10b14e3b8a2' 
  AND token = 'sW2m6GS3yTcH7XHFWA2+2xXhYhOzcaGpZi89FjVw2ic=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}