SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '99c6b91849fb5da42422b056df75a601bcaeea16c86b0200580ea4346da80f50' 
  AND token = 'ZR8fBBYDqfa7XkwlS2NGc4rQYqEnWHtULZUPnJX7yvM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}