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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53f8a6ae5fd57c7549c88c44197f96111d3cefd7530d0983f31d648377c1f28e' 
  AND token = 'K/51vvQDmYwwKAeRCYDOnKFCtwY+j1CtGw11E9EnNZo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}