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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80814fa9638532986c9032f3c960f609980d8a29a73593663a127bb423c7f1ba' 
  AND token = 'ME+zxVlf4nsrCcyVqb5PGHN+5pWjYM02f8nAvInL8+M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}