SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378387440167ebbc0334d877fdc5ca1b9935e3e5b956d01ebc7435a0bcc32fce' 
  AND token = '1ACAFsdpbVBBygzEX4caOwVgGPUk/4Sf55Uw+QUDRy0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}