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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21f29d87a82875983cfc9f1f7b7616cf803d14907cc16f158156222ff6d8177d' 
  AND token = 'U5uCp62tNzioCJ2Wly1fc7WDE8t/gZ9226YI4pEygxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}