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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd65f53ebd591dcddf3c8954d093aa354a517d2a8cffb2d8c93ac5350bac24c49' 
  AND token = 'gk3NW4N8wsY0NiBD0fgZDN81VzHIrWYkAQnHtaVVL8Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}