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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b80491e13684f219f4c154d83f2c991fe000f1fff5ec08e13e07f76071fa06a4' 
  AND token = 'Mw21brIt7QCVQHtSzUakSkcP5SL+Nf/Qi3p4YdXaBhw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}