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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78ba4ddc2849f95f3a44a5112734111b983b243be8c1e45a5e9559aa123f750b' 
  AND token = 'UNz2qWtrm0kmu6q+YfLj7fYlFVuNtwoj6rtXGMyXMxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}