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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a0aeee49f1e0c3054e4315bb57f586811b4f36a5b075418efce85f03cf72dbd' 
  AND token = 'UyMmIOeXpxMkzBgtM/F/utYRG6Wpdl7W+ND7QGiU8Tg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}