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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '15bdb1c8e49307d9dfe092cfd4e0dae2c261ea4638f34f622404d27188da5475' 
  AND token = 'cwt91KvLPqnIng1AdF+GNN/LzxJp6pTn90HUMW1aFsk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}