SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '978fe98246f6ddad279e4216b19ce726a4a7af614ddb13c24da212f6ab7d0d9a' 
  AND token = 'Pwd1T5d5bMQSHvBWTPvOmxx1Br7XCYdw1na5oxmpsfM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}