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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2195c5a658e2919782bceef8be4de321d52865cf8d36354bb7e384ad89ab2a22' 
  AND token = 'NE2hHZ4suFOO2B/YczbfCcMdKpwUXneUmbKR9P8kcQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}