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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40e4fb4464e413491ff6b4fdac223cfb09b9a1a0e2fddadb52544fdd1f09f285' 
  AND token = 'JoiO0RnUGt3p3vBAXCzsqgzYM2MR9c1zqLR0EDMeqNQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}