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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5489adf3af55496152c6cd1b831f26b45d3c0135db0ddb3bfc54067633ff69f' 
  AND token = '1wmfvw4IvUvPfN/9QZwcpFtpibgx27n13eqv4QkCvXw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}