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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43e009dfbfc85677a0d4ed71f8e03a6ef3e01a93255e9769e3e6fdc1648182e5' 
  AND token = 'aHUoSxD/+tQ+aa+8mUlyVQ6RWTzh68LIaWWC5e3IdW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}