SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4f6107cf269f607caf500e9c0f35a287b1c850d461ac7acd8b8efcd53551e008' 
  AND token = 'KBQQEx5QS3BF5u/B0p7BWak0osQFNRy9GyEkHp5b9+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}