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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c01f2cedaad62b820714c9c08648b023b3e35925a1d7a28196bb60a3303e278d' 
  AND token = 'MQL8EBETUdhXg2n3FC6c1fCiGgwUOIPhEqqj0xapqQk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}