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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f0f9110f37bb45f8936741046ffc7aa3bd37acc2e2d15b4c3dc9e7666a80716' 
  AND token = 'FGUmmPE4qTpUYweUXpps5bW6ku231Ct7rvhTflD2Ugo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}